Methylamine → HCID 11722609, compound

Participants

Reaction Steps

α-(4-Chlorophenyl)-α-mercaptoacetic acid (5.0 g, 0.025 mol) prepared in Reference Example 4, nicotinaldehyde (2.64 g, 0.025 mol) and 40% aqueous methylamine solution (5.75 g, 0.074 mol) were added to toluene (50 ml) and the mixture was subjected to azeotropic dehydration for 3 hours. After cooled, the mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (5% acetone-chloroform) and then recrystallized from ether to obtain 5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)-thiazolidin-4-one (6.59 g, yield 87.6%). m.p. 100°-101.5° C.

Provenance & Evidence