Toluene → HCID 19830852, compound

Participants

Reaction Conditions

Reaction Steps

The experiment is carried out as in Example 1, starting with 2-(3-chloropropyl)naphtho[1,8-cd]isothiazole 1,1-dioxide (3.9 g), triethylamine (1.9 cc), 4-[bis(4-fluorophenyl)methylene]piperidine (3.7 g) and sodium iodide (2.1 g) in toluene (150 cc). The mixture is heated for 6 hours at boiling point, then cooled to a temperature of about 20° C. After purification by flashchromatography on a silica column., under a current of argon at medium pressure (0.5-1.5 bar) with dichloromethene as eluant, 2-(3-[bis(4-fluorophenyl)-4-methylenepiperidino]propyl}naphtho[1,8-cd]-isothiazole 1,1-dioxide (4.6 g) is obtained in the form of a brown oil which is converted to the hydrochloride, m.p. 137° C.

Provenance & Evidence