Ammonium Chloride → HCID 178433695, compound

HRID 1493339Notes

Reaction equation

HRID 1493339 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([NH:12][CH2:13][C@H:14]([S:16][CH2:17][C:18]2[N:19]=[CH:20][NH:21][C:22]=2[CH3:23])[CH3:15])=[NH:11])[N:3]=[CH:2]1.C(NC(N)=N)#N.[Cl-:30].[NH4+]>>[ClH:30].[ClH:30].[ClH:30].[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([NH:12][CH2:13][C@H:14]([S:16][CH2:17][C:18]2[N:19]=[CH:20][NH:21][C:22]=2[CH3:23])[CH3:15])=[NH:11])[N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 25517Ammonium ChlorideHCID 178418324HCID 178418324, compoundHCID 178433694HCID 178433694, compound

Product 1

HCID 178433695HCID 178433695, compound

Procedure

(R)-(+)-N-[3-(imidazol-4-yl)propyl]-N'-[2-[(5-methylimidazol-4-yl)methylthio]-1-propyl]-guanidine ##STR95## prepared by a method analogous to that of Example 39 from 0.63 g (1.7 mmol) of the previously prepared cyanoguanidine. 0.85 g of a hygroscopic foam composed of equimolar quantities of ammonium chloride and (R)-(+)-N-[3-(imidazol-4-yl)propyl]-N'-[2-[(5-methylimidazol-4-yl) methylthio]-1-propyl]guanidine trihydrochloride is obtained as residue.

Sources & evidence

ORD record
ord-0696625ed5f24c44bfce6a0aee6ecef6
Source dataset
uspto-grants-1991_06
Patent number
US05021431

Reaction notes

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