Ammonium Chloride → HCID 178433670, compound

HRID 1493340Notes

Reaction equation

HRID 1493340 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([NH:12][C@@H:13]([CH3:23])[CH2:14][S:15][CH2:16][C:17]2[N:18]=[CH:19][NH:20][C:21]=2[CH3:22])=[NH:11])[N:3]=[CH:2]1.C(NC(N)=N)#N.[Cl-:30].[NH4+]>>[ClH:30].[ClH:30].[ClH:30].[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([NH:12][C@@H:13]([CH3:23])[CH2:14][S:15][CH2:16][C:17]2[N:18]=[CH:19][NH:20][C:21]=2[CH3:22])=[NH:11])[N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 25517Ammonium ChlorideHCID 178418324HCID 178418324, compoundHCID 178433669HCID 178433669, compound

Product 1

HCID 178433670HCID 178433670, compound

Procedure

(S)-(+)-N-[3-(imidazol-4-yl)propyl]-N'-[1-[(5-methyl-imidazol 4-yl)methylthio]-2-propyl]-guanidine ##STR101## prepared by a method analogous to that of Example 39 from 0.58 9 (1.6 mmol) of the previously prepared cyanoguanidine. 0.8 g of a hygroscopic foam composed of equimolar quantities of ammonium chloride and (S)-(+)-N-[3-(imidazol-4-yl)propyl]-N'-[1-[(5-methylimidazol-4-yl)methylthio]-2-propyl]-guanidine trihydrochloride is obtained as residue.

Sources & evidence

ORD record
ord-fb95d73f06c342bc8bfecb26ff47967a
Source dataset
uspto-grants-1991_06
Patent number
US05021431

Reaction notes

Loading…