HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminomethyl-1-ethylpyrrolidine → (+/-) 5-Carbomethoxy-N-[1-ethyl-2-pyrrolidinylmethyl]-3-methoxy-4-methylthiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| Reactant | Dimethyl 3-methoxy-4-methyl-2,5-thiophene dicarboxylate | HCID 19831300 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (+/-) 5-Carbomethoxy-N-[1-ethyl-2-pyrrolidinylmethyl]-3-methoxy-4-methylthiophene-2-carboxamide | HCID 21625033 | — |
Reaction Steps
The above compound was prepared by heating dimethyl-3-methoxy-4-methyl-2,5-thiophene dicarboxylate and (±)2-(aminomethyl)-1-ethyl-pyrrolidine at 170° under nitrogen atmosphere. After column chromatography, the title compound was obtained, as its fumarate salt, m.p. 155°-156° ex ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05021449 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-7e0cffbfaa234ae081bd10e50964b3bc |
| Source note | uspto-grants-1991_06 |