Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | 1-Iodonaphthalene | HCID 7004 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13671201 | HCID 13671201 | — |
Reaction Steps
A mixture of 17.8 g of 1-iodo-naphthalene, 4.4 g of paraformaldehyde, 10.4 ml of acetic acid, 14.6 ml of concentrated hydrochloric acid and 6.6 ml of phosphoric acid was stirred at 80 to 85° C. and thereto another 20 ml of concentrated hydrochloric acid was added with stirring 8 times at intervals of 1 hour. The reaction mixture was poured into water and was extracted with benzene. After distilling away benzene, 18.5 g of 4-iodo-1-chloromethylnaphthalene was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05021458 |
|---|
| Source dataset | uspto-grants-1991_06 |
|---|
| ORD ID | ord-cfb6797af71045bc95733af06dfb2a66 |
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| Source note | uspto-grants-1991_06 |
|---|
