HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butylamine → 4-Butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | N-cyclohexyloxy-4-oxo-2,2,6,6-tetramethylpiperidine | HCID 22019868 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine | HCID 21182129 | 93% |
Reaction Steps
A mixture of 9.5 grams (37.5 mmol) of 1-cyclohexyloxy-2, 2,6,6-tetramethylpiperidin-4-one, 13.7 grams (187 mmol) of n-butylamine, 0.4 gram of platinum oxide, and 120 ml of ethanol is hydrogenated on a Parr apparatus (50 psi, ambient temperature) till hydrogen uptake ceases. The catalyst is removed by filtration and the filtrate is evaporated to afford 10.8 grams (93% yield) of the title compound as a colorless syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05021481 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-92bc46701d1a47ceb4a90b541d5d45f2 |
| Source note | uspto-grants-1991_06 |