HRID1493426

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13118721

{2-Hydroxy-4-[(oxiran-2-yl)methoxy]phenyl}(phenyl)methanone

C16H14O4

HCID21182129

未命名化合物

PRODUCTS

生成物

结构：CCCCN(CC(O)COc1ccc(C(=O)c2ccccc2)c(O)c1)C1CC(C)(C)N(OC2CCCCC2)C(C)(C)C1

HCID19831356

未命名化合物

收率 92%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 4.0 g (14.8 g mmol) of 2-hydroxy-4-(2,3-epoxypropoxy)benzophenone, 6.9 g (22.2 mmol) of 4-butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine, and 40 ml of ethanol is heated at reflux for 4 hours. Ethanol is evaporated, and the residue is purified by flash chromatography on silica gel (4:1 heptane: ethyl acetate) to afford 7.9 g (92% yield) of the title compound, a yellow oil.

WORKUP

后处理

temperatureis heated
temperatureat reflux for 4 hours
customEthanol is evaporated
customthe residue is purified by flash chromatography on silica gel (4:1 heptane: ethyl acetate)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a570d021a0e74516a4da3eca9e2dd342
来源数据集: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05021478
来源说明: uspto-grants-1991_06

反应 SMILES

[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH2:17][CH:18]2[O:20][CH2:19]2)[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH2:21]([NH:25][CH:26]1[CH2:31][C:30]([CH3:33])([CH3:32])[N:29]([O:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)[C:28]([CH3:42])([CH3:41])[CH2:27]1)[CH2:22][CH2:23][CH3:24]>C(O)C>[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH2:17][CH:18]([OH:20])[CH2:19][N:25]([CH2:21][CH2:22][CH2:23][CH3:24])[CH:26]2[CH2:31][C:30]([CH3:32])([CH3:33])[N:29]([O:34][CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:28]([CH3:42])([CH3:41])[CH2:27]2)[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:5]