Dimethyl Sulfoxide → HCID 15307547, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 80.5 g (0.5 mol) of 4-phenyl-2-pyrrolidone, 70 g (1.25 mol) of potassium hydroxide, 500 ml of dimethylsulphoxide and 150 ml of toluene are heated at reflux under stirring at the reaction mixture temperature of 130° C. till a complete dispergation of the alkali, whereafter the mixture is dropwise added with 153 g (1.25 mol) of ethylchloroacetate and allowed to stand at room temperature for one day. The mixture is diuted with 1.2 l of water and extracted twice with 100 ml portions of toluene; the extracts are subjected to fractionation to give 73.2 g (47%) of (2-oxo-4-phenyl-1-pyrrolidinyl)acetic acid carboethoxymethyl ester, b.p. 210°-214° C. (1 mm Hg), nD20 =1.5212.

Provenance & Evidence