1-Methylpiperazine → HCID 19829973, compound

Participants

Reaction Steps

Grams 2.5 3-benzyl-2-chloro-3H-imidazo[4,5-b]pyridine and 4 ml N-methylpiperazine are heated at 130°-140° C. for 2 hours, then it is cooled, taken up with a few milliliters of chloroform, and separated by chromatography on silica gel column, first eluting with chloroform and then with chloroform:methyl alcohol (95:5). Therefore it is obtained 1 g 3-benzyl-2-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridine, which is dissolved in 5 ml absolute ethyl alcohol and added to a solution of 0.8 g fumaric acid in 15 ml absolute ethyl alcohol. It is kept under stirring overnight, the crystallized solid is separated and washed with absolute ethyl alcohol to obtain 0.8 g 3-benzyl-2-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridine fumarate melting at 165°-166° C.

Provenance & Evidence