N,N-Dimethylethylenediamine → HCID 21647625, compound

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Reaction Steps

Grams 5 of 3-benzyl-2-chloro-3H-imidazo[4,5-b]pyridine and 9 ml N,N-dimethylethylenediamine are refluxed for 3 hours, then the amine in excess is removed by evaporation under vacum, the oily residue taken up with absolute ethyl alcohol and 10 ml 32% hydrochloric acid are added thereto, the solid crystalline filtered and washed with absolute ethyl alcohol. It is evaporated till dryness and 2.1 g 3-benzyl-2-(2-dimethylaminoethylamino)-3-H-imidazo[4,5-b]pyridine dihydrochloride melting at 262°-264° C. (with decomposition) are obtained.

Provenance & Evidence