Methanol → 4-Hydroxymidazolam

HRID 149357Notes

Reaction equation

HRID 149357 reaction equation
[C:1](=[O:2])([CH3:3])[O:4][CH:5]1[c:6]2[n:7]([c:24]([CH3:27])[n:25][cH:26]2)-[c:8]2[c:9]([cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[C:10]([c:12]2[c:13]([F:18])[cH:14][cH:15][cH:16][cH:17]2)=[N:11]1.[CH3:28][OH:29].[CH3:30][O-:31].[Na+:32]>>[OH:4][CH:5]1[c:6]2[n:7]([c:24]([CH3:27])[n:25][cH:26]2)-[c:8]2[c:9]([cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[C:10]([c:12]2[c:13]([F:18])[cH:14][cH:15][cH:16][cH:17]2)=[N:11]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 3826051MethoxideHCID 155632698-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl acetate

Product 1

HCID 1244494-Hydroxymidazolam

Sources & evidence

ORD record
ord-f3aba4f03c4743cc925016b53a78f966
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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