Ethanol → HCID 19830020, compound

Participants

Reaction Steps

1.6 ml of ethylamine and 2.2 ml of formaldehyde (37% aqueous), dissolved in 30 ml of ethanol, are added to 3.0 g of 1-nitro-2-dimethylamino-2-(N-pyridin-3-ylmethylamino)-ethylene, and the whole is stirred at room temperature for 24 hours. After concentrating the reaction solution by evaporation in a rotary evaporator under a water-jet vacuum, the residue is purified by column chromatography over silica gel. The column is eluted with dichloromethane/10% methanol. After evaporating the solvent in vacuo, the end product, which is obtained in the form of yellowish crystals, is isolated. M.p. 97-98° C.

Provenance & Evidence