Dimethylcarbamoyl Chloride → HCID 14819625, compound

Participants

Reaction Steps

In 1.0 ml of dry N,N-dimethylformamide was dissolved 100 mg of 3,9-dihydroxy-5H-benzofuro[3,2-c]quinolin-6-one. To the solution were added successively 7.8 μl of triethylamine, 40 mg of dimethylcarbamyl chloride and 3 mg of 4-dimethylaminopyridine, and the mixture was stirred for 15 hours at room temperature. The reaction mixture was evaporated under reduced pressure. The residue was purified by preparative silica gel thin layer chromatography (developing solvent: chloroform/methanol/ethyl ether=10/1/2 by volume) to obtain 40 mg of 3-(N,N-dimethylcarbamoyloxy)-9-hydroxy-5H-benzofuro[3,2-c]quinolin-6-one and 25 mg of 9-(N,N-dimethylcarbamoyl)-3-hydroxy-5H-benzofuro[3,2-c]quinolin-6-one.

Provenance & Evidence