Sodium Bicarbonate → 4-(4-(4-Pyridyl)piperazin-1-yl)phenol

Participants

Reaction Steps

A mixture of the product of part (i) (0.7 g, 2.6 mmole) and 48% hydrobromic acid (10 ml) was heated under reflux under a nitrogen atmosphere overnight. The hydrobromic acid was removed by concentration under reduced pressure, the residue dissolved in water and the solution obtained was basified with aqueous sodium bicarbonate solution. The resulting precipitate was removed by filtration and washed with methylene chloride to yield the desired product, m.p. 275°-276° (0.276 g, 41%).

Provenance & Evidence