HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroacetate → HCID 23001581, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroacetate | HCID 7295 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Benzyloxyaniline hydrochloride | HCID 2723831 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 23001581 | HCID 23001581 | — |
Reaction Steps
4-Benzyloxyaniline hydrochloride (70 g), methyl chloroacetate (49 ml) and sodium bicarbonate (75 g) in dry acetonitrile (200 ml) were heated at reflux for 6.5 h. Work up according to the method of Intermediate 8 gave a solid which was recrystallised from chloroform-hexane to give the title compound (55 g), m.p. 106°-107°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05023255 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-e838fce9750a4f70a7c433cdf338b1f3 |
| Source note | uspto-grants-1991_06 |