Water → HCID 19829823, compound

Participants

Reaction Steps

A solution of sodium methoxide (2.17M in methanol; 3 ml) was added to a stirred solution of methyl [2-(aminocarbonyl)-1-(3-methylphenyl)hydrazino]acetate (0.5 g) in methanol (1 ml), and the mixture was stirred at 20° for 1.0 h. Water (20 ml) was added, followed by pH 6.5 phosphate buffer solution (30 ml), and the mixture was extracted with ethyl acetate (3×80 ml). The combined extracts were washed with water (2×80 ml) and saturated brine (80 ml), dried, and evaporated in vacuo to give a solid which was triturated with ether (30 ml) to give the title compound (261 mg), m.p. 245°-247°.

Provenance & Evidence