Hydrochloric Acid → HCID 19829860, compound

Participants

Reaction Steps

The urea, (Intermediate 59, 2.26 g, 7.5 mmol) and sodium methoxide (525 mg; 9.7 mmol) were stirred under nitrogen in methanol (20 ml) for 2 h. A further amount of sodium methoxide (100 mg; 1.9 mmol) was added and the reaction left overnight. The reaction was neutralised with acid (2N HCl) and the precipitate was filtered. The precipitate was recrystallised several times from dioxan to give the title compound (357 mg; 18%).

Provenance & Evidence