Urea → HCID 19829859, compound

Participants

Reaction Steps

Sodium methoxide (467 mg, 8.6 mmol) was added to a stirred solution of the urea (Intermediate 80, 1 g, 2.88 mmol) in methanol (40 ml) and the mixture was stirred at 20°-25° for 2 h. The mixture was poured into pH6.7 buffer (100 ml) and extracted with ethyl acetate (3×100 ml). The combined extracts were washed with water (2×100 ml) and brine (100 ml) before drying (Na2SO4) and evaporating in vacuo to a yellow solid. Trituration with ether gave the title compound as a white solid (265 mg, 29%) m.p. 185°-187° (dec).

Provenance & Evidence