Carbon Dioxide → HCID 86744834, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg) in 2 ml of 2-(2-chloroethoxy)ethanol was stirred at room temperature and under nitrogen for 45 minutes with 300 mg of a 1.6% solution of KOH in 2-(2-chloroethoxy)ethanol. The reaction mixture was decomposed with excess dry ice while immersing the flask into a water bath at room temperature. The reaction product was chromatographed on a silica gel column using first chloroform, which elutes the 2-(2-chloroethoxy)ethanol and then acetone, which elutes the product. The latter was purified twice by preparative thin layer chromatography on silica gel using chloroform as a solvent in the first purification and chloroform-acetone 1:1 in the second purification. This procedure gave 74 mg (58%) of the title compound, having a melting point of 101°-104° C. (decomposition) and providing the following analysis:

Provenance & Evidence