Carbon Dioxide → HCID 86744840, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg) in 2 ml of 1-methyl-3-pyrrolidinol was stirred at room temperature and under nitrogen for 30 minutes with 500 mg of a 1.6% solution of KOH in 1-methyl-3-pyrrolidinol. The reaction mixture was diluted with ether and then decomposed with dry ice. The ether was removed under reduced pressure and the residue left was isolated twice on silica gel using triethylamine as a solvent in the first isolation and 4% of triethylamine in acetone in the second isolation. In both isolation processes the pink substance was extracted from the silica gel with a mixture of triethylamine-acetone 1:3 or 1:4. The extract was concentrated under reduced pressure to give 50 m (42%) of the title compound, having no definite melting point and providing the following analysis:

Provenance & Evidence