Carbon Dioxide → HCID 86744844, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg) in 2 l of 2-phenoxyethanol was stirred at room temperature under nitrogen for 45 minutes with 500 mg of a 1.6% solution of KOH in 2-phenoxyethanol. The reaction product was diluted with ether then decomposed with dry ice. Components of etherial solution were separated on a silica gel column using triethylamine, which elutes the 2-phenoxyethanol, and then a mixture of chloroform and methanol 9:1, which elutes the product. The product was further purified by preparative thin layer chromatography on silica gel with a mixture of chloroform and acetone 6:4. This procedure gave 93 mg (71%) of the title compound, having a melting point of 153°-155° C. and providing the following analysis:

Provenance & Evidence