Barium Carbonate → HCID 178441394, compound

Participants

Reaction Steps

0.088 g (0.446 millimoles) of barium carbonate and 0.169 g (0.892 millimoles) of p-toluene sulfonic acid monohydrate are heated to boiling in 20 ml of methanol until all the substance goes into solution. The colorless hot solution thus obtained is poured into a suspension of 0.1 g (0.887 millimoles) of primycin sulfate and 80 ml of methanol. The reaction mixture is heated to boiling for 15 minutes under constant stirring. The hot mixture is filtered through Celite. The filtrate is evaporated in vacuo. The residue is suspended in a 2:1 mixture of acetone and water, filtered and washed with the above solvent mixture. Thus 1.05 g of white primycin tosylate are obtained, yield 93.3%. The salt decomposes on heating, /α/D25 =-3.9°.

Provenance & Evidence