Chloroacetic Acid → HCID 178441402, compound

Participants

Reaction Steps

0.088 g (0.446 millimoles) of barium carbonate and 0.21 g (2.23 millimoles) of monochloro acetic acid are dissolved in 10 ml of a 1:1 mixture of methanol and water under heating. The still hot solution is added to a suspension of 1.0 g (0.887 millimoles) of primycin sulfate and 70 ml of methanol. The reaction mixture is heated to boiling for 10 minutes under constant stirring, the precipitated barium sulfate is filtered through Celite. The filtrate is evaporated in vacuo. The solid residue is treated with ether. The white powdery solid is washed on the filter three times with 10 ml of ether saturated with water each and dried to constant weight. Thus 0.97 g of primycin monochloroacetate is obtained, yield 93.3%. Mp.: 176° C., /α/D25 =+22.0°.

Provenance & Evidence