Iodoethane → HCID 131716910, compound

Participants

Reaction Steps

4.0 g of ethyl 2-thiooxamate was dissolved in 70 ml of methylene chloride in a nitrogen atmosphere. To this solution, 5.2 g of ethyl iodide was added dropwise at room temperature. After completion of the dropwise addition, the mixture was reacted with stirring for an additional 5 hours to obtain ethyl ethoxycarbonylformthioimidate hydrogen iodide [H5C2O2CC(SC2H5)=NH.HI]. Then, the methylene chloride was evaporated off under reduced pressure, and the residue was mixed with 35 ml of acetic acid, 4.9 g of anhydrous sodium acetate and 5.2 g of phenacylamine hydrochloride (the same as used in Synthesis Example 2), followed by reacting the mixture at 90° to 100° C. for 3 hours.

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