1-(4-Pyridinyl)-1-propanone → HCID 53862819, compound

HRID 1493701Notes

Reaction equation

HRID 1493701 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)(=O)[CH2:2][CH3:3].[C:11]([O:15][CH3:16])(=[O:14])[NH:12][NH2:13]>C(O)C>[N:8]1[CH:9]=[CH:10][C:5]([C:1](=[N:13][NH:12][C:11]([O:15][CH3:16])=[O:14])[CH2:2][CH3:3])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 743431-(4-Pyridinyl)-1-propanoneHCID 80519Methyl carbazate

Product 1

HCID 53862819HCID 53862819, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4.05 gm (0.03 mole) of 4-propionylpyridine, 2.70 gm (0.03 mole) of methyl carbazate and 100 ml of absolute ethanol is refluxed 6 hr. The solution is evaporated in vacuo to give a solid. The crude product is crystallized from ethyl acetate/Skellysolve B to yield 3.90 gm (63%) of the title compound having a melting point of 216.2° C. (decomp.).

Workup

  1. customThe solution is evaporated in vacuo
  2. customto give a solid
  3. customThe crude product is crystallized from ethyl acetate/Skellysolve B

Sources & evidence

ORD record
ord-9558cb538a5144cdbb29e20fc09c521b
Source dataset
uspto-grants-1991_06
Patent number
US05023334

Reaction notes

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