Acetohydrazide → HCID 3548684, compound

HRID 1493705Notes

Reaction equation

HRID 1493705 reaction equation
[C:1]([NH:4][NH2:5])(=[O:3])[CH3:2].[C:6]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)(=O)[CH3:7]>C(O)C>[N:12]1[CH:13]=[CH:14][C:9]([C:6](=[N:5][NH:4][C:1](=[O:3])[CH3:2])[CH3:7])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 142824-Acetylpyridine

Product 1

HCID 3548684HCID 3548684, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.22 gm (0.03 mole) of acetic acid hydrazide, 3.63 gm (0.03 mole) of 4-acetylpyridine and 100 ml of absolute ethanol is refluxed 2 hr. The hot solution is filtered. The filtrate is diluted with water to the cloud point. The mixture is cooled to room temperature and then chilled in the refrigerator. The product is collected, washed with water and dried to yield 3.63 gm (69%) of the title compound having a melting point of 178.1° C.

Workup

  1. temperatureis refluxed 2 hr
  2. filtrationThe hot solution is filtered
  3. additionThe filtrate is diluted with water to the cloud point
  4. temperaturechilled in the refrigerator
  5. customThe product is collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-85df06d7b7284d26ab495fe3b9b687c8
Source dataset
uspto-grants-1991_06
Patent number
US05023334

Reaction notes

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