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Ethanol → 2-Methylcyclopropanecarboxylic acid [1-(3-pyridinyl)propylidene]hydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-Methylcyclopropane-1-carbohydrazide | HCID 44929 | — |
| 反応物 | 1-(3-Pyridyl)propan-1-one | HCID 74074 | — |
| 反応物 | Ethyl acetate hexane | HCID 21226206 | — |
| 触媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-Methylcyclopropanecarboxylic acid [1-(3-pyridinyl)propylidene]hydrazide | HCID 54479202 | 29.5% |
反応手順
A mixture of 8.0 gm (0.07 mole) of 2-methylcyclopropanecarboxylic acid hydrazide, 9.46 gm (0.07 mole) of ethyl-3-pyridyl ketone, 10 drops of glacial acetic acid and 100 ml of EtOH was refluxed 20 hr. Tlc (9:1 Skellysolve B/Ethyl acetate on silica gel) shows no remaining starting material. The reaction mixture was cooled to room temperature and evaporated in vacuo to give a liquid. The liquid solidified on standing. The solid was slurried in ether, collected and dried to give 4.77 gm (29%) of the title compound having a melting point of 137.3° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05023334 |
| 出典データセット | uspto-grants-1991_06 |
| ORD ID | ord-2754237dc1a7450f85f102c2acdfdd41 |
| 出典メモ | uspto-grants-1991_06 |