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Ethanol → 3-Trifluoromethylbenzoic acid [1-(3-pyridinyl)propylidene]hydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 1-(3-Pyridyl)propan-1-one | HCID 74074 | — |
| 反応物 | 3-(Trifluoromethyl)benzoic acid hydrazide | HCID 2777417 | — |
| 触媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Trifluoromethylbenzoic acid [1-(3-pyridinyl)propylidene]hydrazide | HCID 54045504 | 74% |
反応手順
A mixture of 10.21 gm (0.05 mole) of 3-trifluoromethylbenzoic acid hydrazide, 6.76 gm (0.05 mole) of ethyl-3-pyridyl ketone, 10 drops of glacial acetic acid and 100 ml of absolute ethanol was refluxed 15 hr. The reaction mixture was diluted with water to the cloud point and cooled at room temperature than chilled in the refrigerator. The solids that separated were collected, washed with Skellysolve B and dried to give 11.88 gm (74%) of product having a melting point of 119.4° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05023334 |
| 出典データセット | uspto-grants-1991_06 |
| ORD ID | ord-182e52733ba746e1ae8c58aced55713f |
| 出典メモ | uspto-grants-1991_06 |