Ethanol → Acetic acid [1-(6-methyl-3-pyridinyl)ethylidene]hydrazide

HRID 1493716노트

반응식

HRID 1493716 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][N:3]=1.[C:11]([NH:14][NH2:15])(=[O:13])[CH3:12].C(O)C>CCCCCC>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([C:8](=[N:15][NH:14][C:11](=[O:13])[CH3:12])[CH3:9])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14039AcetohydrazideHCID 952923-Acetyl-6-methylpyridine

생성물 1

HCID 53804808Acetic acid [1-(6-methyl-3-pyridinyl)ethylidene]hydrazide수율 83%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

A mixture of 6.76 gm (0.05 mole) of 2-methyl-5-acetylpyridine, 3.7 gm (0.05 mole) of acetic acid hydrazide and 100 ml of ethanol was refluxed 5 hr. The solution was diluted with Skellysolve B until cloudy. The mixture was cooled to room temperature and then chilled in the freezer. The product was collected, washed ith Skellysolve B and dried to afford 7.93 gm (83%) of the title compound having a melting point of 178.5° C.

후처리

  1. temperaturewas refluxed 5 hr
  2. temperaturechilled in the freezer
  3. customThe product was collected
  4. washwashed ith Skellysolve B
  5. customdried

출처 및 근거

ORD 기록
ord-3791b2f06405478ea99ff3c7a77a538e
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05023334

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