反应详情

A mixture of 6.30 gm (0.0405 mole) of 4-acetyl-3-chloropyridine, 2.46 gm (0.041 mole) of formic acid hydrazide and 100 ml of ethanol was refluxed 18 hr. The mixture was chilled in the freezer to give a solid which was collected in two crops. The product was purified by chromotography [keiselgel 60 (230-400 mesh)] and eluting with 5% methanol/methylene chloride to give 2.56 gm (32%) of white flakes which have a melting point of 175.2° C.

1. temperaturewas refluxed 18 hr
2. temperatureThe mixture was chilled in the freezer
3. customto give a solid which
4. customwas collected in two crops
5. customThe product was purified by chromotography [keiselgel 60 (230-400 mesh)]
6. washeluting with 5% methanol/methylene chloride
7. customto give 2.56 gm (32%) of white flakes which