HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl L-phenylalaninate hydrochloride → L-Phenylalanine, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate | HCID 2734674 | — |
| Solvent | Ethyl ether methylene chloride | HCID 21881112 | — |
| Product | L-Phenylalanine, methyl ester | HCID 736234 | — |
Reaction Steps
N-(N-t-butyloxycarbonyl)-5H-pyrrololyl-2-methyl)-L-phenylalanine methyl ester was prepared from L-phenylalanine methyl ester hydrochloride (4.13 mmol) and Boc-prolinal [4.13 mmol, Hamada and Shiori, Chem. Pharm. Bull. (1982) 30, 1921] utilizing the procedure of the first paragraph of Example 9 to yield, after flash chromatography (15-25% Et2O/CH2Cl2 ; SiO2 gel), 0.588 g (40% yield) of pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05023338 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-09a0790004624e19952ead3e25deface |
| Source note | uspto-grants-1991_06 |