HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → 4-Chlorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Formate | HCID 2723810 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 4-Chlorobenzonitrile | HCID 12163 | — |
Reaction Steps
The compound (I) may be synthesized by reacting 4-chlorobenzaldehyde, sodium formate, hydroxylamine hydrochloride and formic acid to form 4-chlorobenzonitrile, which may be nitrated to form 4-chloro-3-nitrobenzonitrile. Finally, this compound is reacted with the appropriate amine to obtain the desired compound (I) of the present invention.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05024673 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-b40b031ca4674c4caaa01e840737edf0 |
| Source note | uspto-grants-1991_06 |