Ethylene Oxide → 2-(2-Fluoro-1-fluoromethyl-ethoxy)-ethanol

112 g (1.0 mol) of 1,3-difluoro-2-propanol and 3 g of potassium hydroxide are initially introduced and 50 ml of ethylene oxide are condensed in a V4A autoclave (volume : 300 ml) at -78° C. The reaction mixture is then shaken for 12 hours at +80° C. to +90° C. (initial pressure about 9000 hPa). After depressurizing and venting unreacted ethylene oxide, the residual contents of the autoclave are fractionally distilled in a water jet vacuum. 59 g (38 % of theory) of 2-(2-fluoro-1-fluoromethyl-ethoxy)-ethanol are obtained as a main fraction of boiling range 98° C. to 105° C./24 hPa.

1. customcondensed in a V4A autoclave (volume : 300 ml) at -78° C
2. distillationthe residual contents of the autoclave are fractionally distilled in a water jet vacuum

ORD record

ord-f33f157e53b94a69844fd8c537a9a098

Source dataset

uspto-grants-1991_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05024694