Thionyl Chloride → HCID 15177067, compound

HRID 1493826Notes

Reaction equation

HRID 1493826 reaction equation
[CH2:1]([CH:8]([CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[C:9](O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=S(Cl)[Cl:25]>>[CH2:1]([CH:8]([CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[C:9]([Cl:25])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 15177066HCID 15177066, compound

Product 1

HCID 15177067HCID 15177067, compound

Procedure

A solution of 5.0 g (17.2 mmole) of 2-benzyl-3-(1-naphthyl)propionic acid (EP-186,977) in 30 ml SOCl2 was stirred overnight at room temperature. The mixture was stripped to 5.48 g of an oil which was used without further purification in the following reaction.

Workup

  1. customwas used without further purification in the following reaction

Sources & evidence

ORD record
ord-bb8266f83f4941209b16cfeaa2ac1e57
Source dataset
uspto-grants-1991_06
Patent number
US05024994

Reaction notes

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