Sodium Acetate → HCID 22008415, compound

HRID 1493832Notes

Reaction equation

HRID 1493832 reaction equation
Cl[C:2]1[C:3]([OH:21])=[CH:4][C:5]2[CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[F:18])[CH2:10][N:9]([CH3:19])[CH2:8][CH2:7][C:6]=2[CH:20]=1.C([O-])(=O)C.[Na+].[H][H]>C(O)(=O)C.[Pd]>[F:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH:11]1[C:5]2[CH:4]=[C:3]([OH:21])[CH:2]=[CH:20][C:6]=2[CH2:7][CH2:8][N:9]([CH3:19])[CH2:10]1

Participants

6

Reactant 3

HCID 517045Sodium AcetateHCID 22008420HCID 22008420, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22008415HCID 22008415, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

10.0 g 8-chloro-5-(2-fluorophenyl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine was dissolved in 500 ml acetic acid containing sodium acetate. Palladium-on-carbon was added and the suspension was heated to 60° C. Under vigorous stirring hydrogen was led through the suspension giving after 48 h 7,9 g crystalline compound. Yield 72%.

Sources & evidence

ORD record
ord-446f297a574f414fb0bf5fe9bc41d38a
Source dataset
uspto-grants-1991_06
Patent number
US05025009

Reaction notes

Loading…