Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | HCID 22008423 | HCID 22008423 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22008419 | HCID 22008419 | 38.3% |
Reaction Steps
300 mg 7-methoxy-3-methyl-8-nitro-5(2'-methyl-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine was dissolved in MeOH and cooled to -70° C. 1 g BBr3 was added slowly and the mixture was stirred for 1 h at -70° C., and stirring was continued for 1 h. Methanol was slowly added to destroy the excess of BBr3 and the mixture was evaporated to dryness. The raw material was purified by column chromatography (kieselgel, CH2Cl2 /CH3OH: 98/2) giving 110 mg of the desired compound. M.p 59°-61° NMR: C5H 5.10d: C6H 6.20S: C9H 8.05s ppm. respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05025009 |
|---|
| Source dataset | uspto-grants-1991_06 |
|---|
| ORD ID | ord-63b7026382aa4a61811bec7b6fdf165a |
|---|
| Source note | uspto-grants-1991_06 |
|---|
