HCID 12508712, compound → Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-2-(1H-imidazol-2-ylthio)-N-methyl-, monohydrochloride

HRID 1493858Notes

Reaction equation

HRID 1493858 reaction equation
[CH3:1][N:2]([C:19](=[O:22])[CH2:20]Cl)[C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[C:10](=[O:18])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[Cl:17].[SH:23][C:24]1[NH:25][CH:26]=[CH:27][N:28]=1>CO>[ClH:9].[CH3:1][N:2]([C:19](=[O:22])[CH2:20][S:23][C:24]1[NH:25][CH:26]=[CH:27][N:28]=1)[C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[C:10](=[O:18])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[Cl:17]

Participants

4

Reactant 2

HCID 12508712HCID 12508712, compoundHCID 178527877HCID 178527877, compound

Product 1

HCID 3080483Acetamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-2-(1H-imidazol-2-ylthio)-N-methyl-, monohydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 10.68 grams of N-methyl 2'-orthochlorobenzoyl-2,4'-dichloroacetanilide and 2.4 grams of 2-mercaptoimidazole are treated for 8 hours under reflux with methanol. After cooling, evaporation under vacuum, and taking up by an acetone-ether mixture, there is obtained by crystallization the hydrochloride of N-methyl 2'-orthochlorobenzoyl-4'-chloro 2-[(2-imidazolyl)thioacetanilide (9.12 g).

Workup

  1. additionare treated for 8 hours
  2. temperatureAfter cooling
  3. customevaporation under vacuum

Sources & evidence

ORD record
ord-974c49ffbf1f4e23b85155e36150db3b
Source dataset
uspto-grants-1991_06
Patent number
US05025015

Reaction notes

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