N-(1-Benzyl-4-piperidyl)-N-(4-fluorophenyl)-4-fluorobenzamide hydrochloride → HCID 19829436, compound

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Reaction Steps

N-(1-Benzyl-4-piperidyl)-N-(4-fluorophenyl)-4-fluorobenzamide hydrochloride (3.2 g) in 95% strength ethanol (50 cc) is hydrogenated at 60° C. at atmospheric pressure in the presence of palladium hydroxide (0.5 g). After filtration through kieselguhr and concentration to dryness under reduced pressure (5.2 kPa), N-(4-fluorophenyl)-N-(4-piperidyl)-4-fluorobenzamide hydrochloride (2.3 g) is obtained in the form of a white powder, m.p. 170° C.

Provenance & Evidence