Potassium thiocyanate → HCID 53916869, compound

HRID 1493883Notes

Reaction equation

HRID 1493883 reaction equation
[C:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12][CH2:13][CH2:14]Br)=[C:6]([CH2:18][CH2:19][CH3:20])[C:5]=1[OH:21])(=[O:3])[CH3:2].[S-:22][C:23]#[N:24].[K+]>CC(C)=O>[C:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12][CH2:13][CH2:14][S:22][C:23]#[N:24])=[C:6]([CH2:18][CH2:19][CH3:20])[C:5]=1[OH:21])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 13885752HCID 13885752, compound

Product 1

HCID 53916869HCID 53916869, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

(2.8 mMole) S-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]-2-mercaptoethyl bromide and 5.0 g. potassium thiocyanate are heated to reflux for 2 hours in 25 ml. acetone. Subsequently, the precipitate is filtered off with suction, the solution is evaporated and the residue is stirred with diethyl ether. After evaporating the diethyl ether, there is obtained 0.7 g. (71% of theory) of the title compound in the form of an oil.

Workup

  1. temperatureto reflux for 2 hours in 25 ml
  2. filtrationSubsequently, the precipitate is filtered off with suction
  3. customthe solution is evaporated
  4. customAfter evaporating the diethyl ether
  5. customthere is obtained 0.7 g

Sources & evidence

ORD record
ord-ff6e2a70d74b4cdba3c0df65efad0f1f
Source dataset
uspto-grants-1991_06
Patent number
US05025028

Reaction notes

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