Phenol → HCID 54032816, compound

Participants

Reaction Steps

This compound was prepared according to the procedure of Example 37. Thus a solution of 16.2 g (0.17 mole) of phenol and 33.0 g (0.21 mole) of N-isopropylsulfamoyl chloride (prepared from isopropylamine, sulfuryl chloride and antimony pentachloride by the procedure of Example 2, part a) in 150 ml of toluene gave a dark oil which was purified by column chromatography on silica gel using ethyl acetate-hexanes (1:16) to elute the product. Desired fractions were combined and concentrated to yield 11.7 g (32%) of the title compound as a light-yellow oil.

Provenance & Evidence