3-(Trifluoromethyl)phenol → HCID 54414453, compound

HRID 1494014Notes

Reaction equation

HRID 1494014 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([OH:9])[CH:4]=1.Cl[S:13]([N:16]=C=O)(=[O:15])=[O:14]>C1(C)C=CC=CC=1>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:4]=[C:5]([O:9][S:13](=[O:15])(=[O:14])[NH2:16])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 73763-(Trifluoromethyl)phenolHCID 70918Chlorosulfonyl isocyanate

Product 1

HCID 54414453HCID 54414453, compoundYield 88.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This compound was prepared according to the procedure used in Example 56. A mixture of 18.4 g (0.114 mole) of α,α,α-trifluoro-m-cresol, 14.8 g (0.105 mole) of chlorosulfonyl isocyanate and 100 ml of toluene gave 22.5 g (82%) of a white solid, mp 100°-102° C.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-7072a3bb7ee64cd89f887a869de3647e
Source dataset
uspto-grants-1991_06
Patent number
US05025031

Reaction notes

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