Chlorosulfamic acid → HCID 45262295, compound

HRID 1494044Notes

Reaction equation

HRID 1494044 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1.[S:14]([Cl:18])(=[O:17])(=[O:16])[NH2:15]>C(#N)C>[ClH:18].[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[C:9]([O:13][S:14](=[O:17])(=[O:16])[NH2:15])[CH:10]=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 24499Chlorosulfamic acidHCID 10058013HCID 10058013, compound

Product 1

HCID 45262295HCID 45262295, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A slurry of 8.7 g (0.05 mole) of 3-(2-methyl-1H-imidazol-1-yl)phenol in 150 ml of acetonitrile was treated with a solution of 0.05 mole of sulfamoyl chloride in 20 ml of acetonitrile. The mixture dissolved and slowly deposited off-white crystals over the period of 24 hr. The precipitate was collected and triturated with hot absolute ethanol. The slurry was cooled and the precipitate was collected and dried to give 4.0 g (32%) of an off-white powder, mp 197°-200° C.

Workup

  1. dissolutionThe mixture dissolved
  2. customover the period of 24 hr
  3. customThe precipitate was collected
  4. customtriturated with hot absolute ethanol
  5. temperatureThe slurry was cooled
  6. customthe precipitate was collected
  7. customdried

Sources & evidence

ORD record
ord-a19438478dff41f7bba80c8daf809cfc
Source dataset
uspto-grants-1991_06
Patent number
US05025031

Reaction notes

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