反应详情

To a solution of 2.62 g (5.6 mmol) of methyl 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)propyl]-octanoate. in 14 mL dioxane is added 11.6 mL of 1N NaOH (11.6 mmol) and the mixture is heated at 60° for 2 hours. The solvent is evaporated and the residue dissolved in water. The pH of the aqueous solution is adjusted to 5.0 using 2N aqueous HCl. The resulting mixture is extracted with methylene chloride (3×20 mL). The combined organic extract is dried (MgSO4), filtered and subjected to evaporation to give an oil. Crystallization from ether yields 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)propyl]-octanoic acid, m.p. 114-116°.

1. temperaturethe mixture is heated at 60° for 2 hours
2. customThe solvent is evaporated
3. dissolutionthe residue dissolved in water
4. extractionThe resulting mixture is extracted with methylene chloride (3×20 mL)
5. extractionThe combined organic extract
6. dry with materialis dried (MgSO4)
7. filtrationfiltered
8. customsubjected to evaporation
9. customto give an oil
10. customCrystallization from ether