4-Chlorobenzenesulfonyl chloride → HCID 10343879, compound

Participants

Reaction Steps

To a solution of 0.127 g (9.045 mmol) of methyl 8-amino-5-[2-(3-pyridyl)ethyl]-octanoate in 5 mL methylene chloride are added a few crystals of 4-dimethylaminopyridine followed by 0.1 mL (0.7 mmol) triethylamine and 0.112 g p-chlorophenylsulfonyl chloride, and the solution is stirred at room temperature for 16 hours. The reaction is diluted with 10 mL methylene chloride and washed with saturated aqueous sodium bicarbonate solution. The organic phase is dried (MgSO4), filtered and evaporated to obtain an oil which is purified by preparative thin layer chromatography to give methyl 8-(p-chlorophenylsulfonamido)-5-[2-(3-pyridyl)ethyl]-octanoate as an oil.

Provenance & Evidence