反应详情

To a solution of 1.83 g of methyl 2,2-dimethyl-4-[3-(3-pyridyl)-2-propenyl]-8-(t-butyldimethylsiloxy)-octanoate in 50 mL ethanol is added 0.18 g of 10% palladium on carbon. The mixture is hydrogenated at 3 atmospheres pressure in a Parr apparatus for 7.5 hours. The catalyst is filtered off and washed with ethanol. The solvent is evaporated to give methyl 2,2-dimethyl-4-[3-(3-pyridyl)-propyl]-8-(t-butyldimethylsiloxy)-octanoate as an oil; NMR (CDCl3): delta 3.58 (s,3H), 3.55 (t,2H), 2.57 (t,2H), 1.13 (s,6H).

1. filtrationThe catalyst is filtered off
2. washwashed with ethanol
3. customThe solvent is evaporated