Tributyltin azide → HCID 178526988, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.528 g 8-(p-chlorophenylsulfonamido)-4[3-(3-pyridyl)propyl]octanenitrile and 1.04 mL tributyltin azide in 5 mL tetrahydrofuran is heated at 120° C. for 64 hours. The solvent is evaporated and subjected to flash chromatography over silica gel using methylene chloride/hexane/methanol/acetic acid (45:25:5:0.8) as eluent to give an oil which is purified again by preparative thin layer chromatography using methylene chloride, methanol, hexane, acetic acid (45:5:25:0.8) as eluent to yield an oil which is triturated with ether and hexane to give 5-{7-(p-chlorophenylsulfonamido)-3-[3-(3-pyridyl)-propyl]-heptyl}-1H-tetrazole hemihydrate, m.p. 56-81°.

Provenance & Evidence