Methyl iodide → HCID 15680041, compound

HRID 1494198Notes

Reaction equation

HRID 1494198 reaction equation
[OH:1][C@H:2]1[CH2:30][C@@:29]2([CH3:31])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:32])[C:17](=[O:28])[CH2:18][O:19][C:20]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[O:21])[C@H:12]2[C@H:3]1[C@:4]1([CH3:34])[C:9]([CH2:10][CH2:11]2)=[CH:8][C:7](=[O:33])[CH2:6][CH2:5]1.[CH3:35][I:36]>CC(C)=O>[I-:36].[CH3:35][N+:24]1[CH:25]=[CH:26][CH:27]=[C:22]([C:20]([O:19][CH2:18][C:17](=[O:28])[C@:16]2([OH:32])[C@:29]3([CH3:31])[C@H:13]([C@H:12]4[C@H:3]([C@@H:2]([OH:1])[CH2:30]3)[C@:4]3([CH3:34])[C:9](=[CH:8][C:7](=[O:33])[CH2:6][CH2:5]3)[CH2:10][CH2:11]4)[CH2:14][CH2:15]2)=[O:21])[CH:23]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 15680040HCID 15680040, compound

Product 1

HCID 15680041HCID 15680041, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The product of Example 119 (1 g, 2.1 mmol) was dissolved in 50 mL of acetone and 4 mL of methyl iodide were added. The solution was stirred at the reflux temperature overnight. Removal of the solvent gave the title compound as a yellow powder in 98% yield. Elemental analysis confirmed that the product had the formula: ##STR148##

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-7ead7b0e5e2446a389653af1b2c01862
Source dataset
uspto-grants-1991_06
Patent number
US05024998

Reaction notes

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