HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 4-[6-(2,3-Dimethoxyphenyl)hexyloxy]-2-hydroxybenzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2,4-Dihydroxybenzoate | HCID 16523 | — |
| Reactant | 1-(6-Bromohexyl)-2,3-dimethoxybenzene | HCID 14986283 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-[6-(2,3-Dimethoxyphenyl)hexyloxy]-2-hydroxybenzoic acid methyl ester | HCID 14986338 | 93.6% |
Reaction Steps
A mixture of 1.0 g (3.3 mmol) of 1-(6-bromohexyl)-2,3-dimethoxybenzene, 0.55 g (3.3 mmol) of 2,4-dihydroxybenzoic acid methyl ester, 1.2 g (9 mmol) of potassium carbonate and 0.75 g (4.5 mmol) of potassium iodide in 25 mL of acetone was stirred at reflux for 20 hours. Workup as in Example 16 gave 1.2 g of 4-[6-(2,3-dimethoxyphenyl)hexyloxy]-2-hydroxybenzoic acid methyl ester as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05025036 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-127a9b5db86f429ea3ebe42756341005 |
| Source note | uspto-grants-1991_06 |