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Sodium Iodide → 4-Nitro-3-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid phenylmethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(6-Bromohexyl)-2,3-bis(phenylmethoxy)benzene | HCID 14986434 | — |
| 反応物 | 3-Hydroxy-4-nitrobenzoic acid benzyl ester | HCID 14986435 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Nitro-3-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid phenylmethyl ester | HCID 14986436 | 64.9% |
反応手順
A mixture of 5.8 g (0.013 mol) of 1-(6-bromohexyl)-2,3-bis(phenylmethoxy)benzene, 3.5 g (0.013 mol) of 3-hydroxy-4-nitrobenzoic acid phenylmethyl ester, 3.5 g (0.026 mol) of anhydrous potassium carbonate and 2.9 g (0.019 mol) of sodium iodide in 125 ml of acetone and 13 ml of dimethylformamide was stirred and heated at reflux for 42 hours. Workup as described in example 16 and purification by HPLC using 10% ethyl acetate-hexane gave 5.45 g of 4-nitro-3-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid phenylmethyl ester as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05025036 |
| 出典データセット | uspto-grants-1991_06 |
| ORD ID | ord-2c7237f2237748b6a65202c925b5d137 |
| 出典メモ | uspto-grants-1991_06 |